Detailed information of TA system TA254678

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1596188..1596767
• Replicon: chromosome
• Accession: NZ_CP102962
• Organism: Staphylococcus aureus strain 16CS0212

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: NW971_RS07775
• Protein ID: WP_001025401.1
• Coordinates: 1596522..1596767 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1596188..1596553 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW971_RS07735 (NW971_07735)	1592930..1593487	-	558	WP_000645045.1	DUF2815 family protein	-
NW971_RS07740 (NW971_07740)	1593513..1594679	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
NW971_RS07745 (NW971_07745)	1594676..1595038	-	363	WP_000985986.1	hypothetical protein	-
NW971_RS07750 (NW971_07750)	1595053..1595376	-	324	WP_000175000.1	hypothetical protein	-
NW971_RS07755 (NW971_07755)	1595456..1595617	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
NW971_RS07760 (NW971_07760)	1595630..1595893	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
NW971_RS07765 (NW971_07765)	1595918..1596133	-	216	WP_001097552.1	hypothetical protein	-
NW971_RS07770 (NW971_07770)	1596188..1596553	+	366	WP_001128433.1	hypothetical protein	Antitoxin
NW971_RS07775 (NW971_07775)	1596522..1596767	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
NW971_RS07780 (NW971_07780)	1596834..1597214	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
NW971_RS07785 (NW971_07785)	1597201..1597398	-	198	WP_001148860.1	hypothetical protein	-
NW971_RS07790 (NW971_07790)	1597468..1597680	+	213	WP_000362644.1	hypothetical protein	-
NW971_RS07795 (NW971_07795)	1597721..1597870	-	150	WP_000771849.1	hypothetical protein	-
NW971_RS07800 (NW971_07800)	1597885..1598328	-	444	WP_000435357.1	hypothetical protein	-
NW971_RS07805 (NW971_07805)	1598345..1598569	-	225	WP_000333485.1	DUF739 family protein	-
NW971_RS07810 (NW971_07810)	1598731..1599111	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
NW971_RS07815 (NW971_07815)	1599133..1599591	+	459	WP_001558059.1	hypothetical protein	-
NW971_RS07820 (NW971_07820)	1599609..1600043	+	435	WP_000755718.1	hypothetical protein	-
NW971_RS07825 (NW971_07825)	1600072..1600467	+	396	WP_001558060.1	hypothetical protein	-
NW971_RS07830 (NW971_07830)	1600557..1600703	+	147	WP_001795334.1	hypothetical protein	-
NW971_RS07835 (NW971_07835)	1600700..1601314	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1554421..1620290	65869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T254678 WP_001025401.1 NZ_CP102962:c1596767-1596522 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT254678 NZ_CP102962:1596188-1596553 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin