Detailed information of TA system TA254676

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1098186..1098765
• Replicon: chromosome
• Accession: NZ_CP102962
• Organism: Staphylococcus aureus strain 16CS0212

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW971_RS05305
• Protein ID: WP_258411822.1
• Coordinates: 1098186..1098419 (+)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1098402..1098765 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW971_RS05265 (NW971_05265)	1093687..1094718	-	1032	WP_258464893.1	site-specific integrase	-
NW971_RS05270 (NW971_05270)	1094825..1095169	-	345	WP_258412914.1	DUF3969 family protein	-
NW971_RS05275 (NW971_05275)	1095169..1095651	-	483	WP_258412915.1	hypothetical protein	-
NW971_RS05280 (NW971_05280)	1095820..1096434	-	615	WP_258464894.1	hypothetical protein	-
NW971_RS05285 (NW971_05285)	1096459..1096920	-	462	WP_258412917.1	toxin	-
NW971_RS05290 (NW971_05290)	1096933..1097265	-	333	WP_258464895.1	helix-turn-helix transcriptional regulator	-
NW971_RS05295 (NW971_05295)	1097429..1097638	+	210	WP_196429541.1	helix-turn-helix transcriptional regulator	-
NW971_RS05300 (NW971_05300)	1097712..1098029	+	318	WP_196429542.1	hypothetical protein	-
NW971_RS05305 (NW971_05305)	1098186..1098419	+	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
-	1098402..1098765	-	364	-	-	Antitoxin
NW971_RS05315 (NW971_05315)	1098821..1099504	+	684	WP_258464897.1	BRO family protein	-
NW971_RS05320 (NW971_05320)	1099520..1099735	+	216	WP_258412921.1	DUF771 domain-containing protein	-
NW971_RS05325 (NW971_05325)	1099750..1099911	+	162	WP_015978262.1	DUF1270 family protein	-
NW971_RS05330 (NW971_05330)	1100006..1100308	+	303	WP_258464898.1	DUF2482 family protein	-
NW971_RS05335 (NW971_05335)	1100313..1100573	+	261	WP_258464900.1	DUF1108 family protein	-
NW971_RS05340 (NW971_05340)	1100582..1100845	+	264	WP_001205732.1	hypothetical protein	-
NW971_RS05345 (NW971_05345)	1100854..1102797	+	1944	WP_258464901.1	AAA family ATPase	-
NW971_RS05350 (NW971_05350)	1102799..1103719	+	921	WP_258464902.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hly/hla	1079673..1135431	55758

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254676 WP_258411822.1 NZ_CP102962:1098186-1098419 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254676 NZ_CP102962:c1098765-1098402 [Staphylococcus aureus]
ATGTCCTTGATATCTGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAATTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTTCATGGTGTGCTTGCAGAC
AACACTATTTATCATGTGACAATATCTGATAAGACTATTGTTTATTTCGAAAATGAGTTTAAAAACAATTTGAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin