254674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2516156..2516679 Replicon chromosome
Accession NZ_CP102961
Organism Staphylococcus aureus strain 03-RR-88

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag NW973_RS12520 Protein ID WP_000074043.1
Coordinates 2516156..2516422 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NW973_RS12525 Protein ID WP_000587618.1
Coordinates 2516422..2516679 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW973_RS12500 (NW973_12500) 2511463..2512650 - 1188 WP_000026189.1 MFS transporter -
NW973_RS12505 (NW973_12505) 2513046..2513822 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
NW973_RS12510 (NW973_12510) 2513815..2514477 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
NW973_RS12515 (NW973_12515) 2514725..2515801 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW973_RS12520 (NW973_12520) 2516156..2516422 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
NW973_RS12525 (NW973_12525) 2516422..2516679 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW973_RS12530 (NW973_12530) 2517038..2517493 + 456 WP_000732090.1 YehR family lipoprotein -
NW973_RS12535 (NW973_12535) 2517661..2519238 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NW973_RS12540 (NW973_12540) 2519433..2520182 + 750 WP_258410828.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T254674 WP_000074043.1 NZ_CP102961:c2516422-2516156 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT254674 WP_000587618.1 NZ_CP102961:c2516679-2516422 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References