Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2458147..2458664 Replicon chromosome
Accession NZ_CP102961
Organism Staphylococcus aureus strain 03-RR-88

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW973_RS12240 Protein ID WP_000113262.1
Coordinates 2458147..2458413 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW973_RS12245 Protein ID WP_000584499.1
Coordinates 2458413..2458664 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW973_RS12210 (NW973_12210) 2453570..2454106 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW973_RS12215 (NW973_12215) 2454339..2455163 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW973_RS12220 (NW973_12220) 2455380..2455562 - 183 WP_000230294.1 hypothetical protein -
NW973_RS12225 (NW973_12225) 2455646..2456113 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW973_RS12230 (NW973_12230) 2456299..2457852 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW973_RS12235 (NW973_12235) 2458041..2458112 - 72 Protein_2363 hypothetical protein -
NW973_RS12240 (NW973_12240) 2458147..2458413 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW973_RS12245 (NW973_12245) 2458413..2458664 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW973_RS12250 (NW973_12250) 2458829..2458909 - 81 WP_223197974.1 hypothetical protein -
NW973_RS12255 (NW973_12255) 2458937..2459536 - 600 WP_000162810.1 DsbA family protein -
NW973_RS12260 (NW973_12260) 2459555..2459917 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW973_RS12265 (NW973_12265) 2460172..2461422 + 1251 WP_258410814.1 FemA/FemB family glycyltransferase FmhA -
NW973_RS12270 (NW973_12270) 2461507..2462238 - 732 WP_258410815.1 amino acid ABC transporter ATP-binding protein -
NW973_RS12275 (NW973_12275) 2462235..2462954 - 720 WP_258410816.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254672 WP_000113262.1 NZ_CP102961:c2458413-2458147 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254672 WP_000584499.1 NZ_CP102961:c2458664-2458413 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References