Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2484511..2485034 Replicon chromosome
Accession NZ_CP102960
Organism Staphylococcus aureus strain 07-G-D

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag NW949_RS12305 Protein ID WP_000074045.1
Coordinates 2484511..2484777 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag NW949_RS12310 Protein ID WP_000587619.1
Coordinates 2484777..2485034 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW949_RS12285 (NW949_12285) 2479817..2481004 - 1188 WP_000026194.1 MFS transporter -
NW949_RS12290 (NW949_12290) 2481400..2482176 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW949_RS12295 (NW949_12295) 2482169..2482831 - 663 WP_258415374.1 ATP-binding cassette domain-containing protein -
NW949_RS12300 (NW949_12300) 2483079..2484155 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW949_RS12305 (NW949_12305) 2484511..2484777 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
NW949_RS12310 (NW949_12310) 2484777..2485034 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW949_RS12315 (NW949_12315) 2485394..2485849 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NW949_RS12320 (NW949_12320) 2486017..2487594 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW949_RS12325 (NW949_12325) 2487789..2488538 + 750 WP_000072458.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T254665 WP_000074045.1 NZ_CP102960:c2484777-2484511 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT254665 WP_000587619.1 NZ_CP102960:c2485034-2484777 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References