Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2428079..2428596 Replicon chromosome
Accession NZ_CP102960
Organism Staphylococcus aureus strain 07-G-D

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW949_RS12030 Protein ID WP_000113262.1
Coordinates 2428079..2428345 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW949_RS12035 Protein ID WP_000584499.1
Coordinates 2428345..2428596 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW949_RS12000 (NW949_12000) 2423503..2424039 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW949_RS12005 (NW949_12005) 2424272..2425096 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW949_RS12010 (NW949_12010) 2425313..2425495 - 183 WP_000230294.1 hypothetical protein -
NW949_RS12015 (NW949_12015) 2425579..2426046 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW949_RS12020 (NW949_12020) 2426232..2427785 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW949_RS12025 (NW949_12025) 2427973..2428044 - 72 WP_223200558.1 hypothetical protein -
NW949_RS12030 (NW949_12030) 2428079..2428345 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW949_RS12035 (NW949_12035) 2428345..2428596 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW949_RS12040 (NW949_12040) 2428761..2428862 - 102 WP_031867537.1 hypothetical protein -
NW949_RS12045 (NW949_12045) 2428869..2429468 - 600 WP_000162810.1 DsbA family protein -
NW949_RS12050 (NW949_12050) 2429487..2429849 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW949_RS12055 (NW949_12055) 2430104..2431354 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
NW949_RS12060 (NW949_12060) 2431451..2432182 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW949_RS12065 (NW949_12065) 2432179..2432898 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254663 WP_000113262.1 NZ_CP102960:c2428345-2428079 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254663 WP_000584499.1 NZ_CP102960:c2428596-2428345 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References