Detailed information of TA system TA254661

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2302159..2302738
• Replicon: chromosome
• Accession: NZ_CP102960
• Organism: Staphylococcus aureus strain 07-G-D

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW949_RS11415
• Protein ID: WP_258411822.1
• Coordinates: 2302505..2302738 (-)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2302159..2302522 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW949_RS11375 (NW949_11375)	2298011..2299954	-	1944	WP_258412923.1	AAA family ATPase	-
NW949_RS11380 (NW949_11380)	2299963..2300226	-	264	WP_001205732.1	hypothetical protein	-
NW949_RS11385 (NW949_11385)	2300235..2300495	-	261	WP_113555199.1	DUF1108 family protein	-
NW949_RS11390 (NW949_11390)	2300500..2300802	-	303	WP_258412922.1	DUF2482 family protein	-
NW949_RS11395 (NW949_11395)	2300897..2301058	-	162	WP_258411818.1	DUF1270 domain-containing protein	-
NW949_RS11400 (NW949_11400)	2301071..2301334	-	264	WP_115207353.1	helix-turn-helix domain-containing protein	-
NW949_RS11405 (NW949_11405)	2301349..2302104	-	756	WP_258415360.1	phage regulatory protein/antirepressor Ant	-
-	2302159..2302522	+	364	-	-	Antitoxin
NW949_RS11415 (NW949_11415)	2302505..2302738	-	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
NW949_RS11420 (NW949_11420)	2302781..2303098	-	318	WP_196429542.1	hypothetical protein	-
NW949_RS11425 (NW949_11425)	2303114..2303332	-	219	WP_258413121.1	helix-turn-helix transcriptional regulator	-
NW949_RS11430 (NW949_11430)	2303475..2304194	+	720	WP_258413122.1	XRE family transcriptional regulator	-
NW949_RS11435 (NW949_11435)	2304205..2305062	+	858	WP_258413123.1	HIRAN domain-containing protein	-
NW949_RS11440 (NW949_11440)	2305155..2305346	+	192	WP_252559444.1	hypothetical protein	-
NW949_RS11445 (NW949_11445)	2305343..2305630	-	288	WP_258415362.1	hypothetical protein	-
NW949_RS11450 (NW949_11450)	2306047..2307252	+	1206	WP_258415363.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2261563..2319776	58213

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254661 WP_258411822.1 NZ_CP102960:c2302738-2302505 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254661 NZ_CP102960:2302159-2302522 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAGTTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTCCATGGTGTGCTTGCAGAC
AACACTATTTATCATGTGACAATATCGGATAAGACTATTGTTTATTTCGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin