Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2455299..2455822 Replicon chromosome
Accession NZ_CP102959
Organism Staphylococcus aureus strain 12-G-51

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag NW979_RS11960 Protein ID WP_000074045.1
Coordinates 2455299..2455565 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag NW979_RS11965 Protein ID WP_000587619.1
Coordinates 2455565..2455822 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW979_RS11940 (NW979_11940) 2450605..2451792 - 1188 WP_000026194.1 MFS transporter -
NW979_RS11945 (NW979_11945) 2452188..2452964 - 777 WP_258413522.1 iron export ABC transporter permease subunit FetB -
NW979_RS11950 (NW979_11950) 2452957..2453619 - 663 WP_258413523.1 ATP-binding cassette domain-containing protein -
NW979_RS11955 (NW979_11955) 2453867..2454943 - 1077 WP_258413524.1 M42 family metallopeptidase -
NW979_RS11960 (NW979_11960) 2455299..2455565 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
NW979_RS11965 (NW979_11965) 2455565..2455822 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW979_RS11970 (NW979_11970) 2456181..2456636 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NW979_RS11975 (NW979_11975) 2456803..2458380 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NW979_RS11980 (NW979_11980) 2458575..2459324 + 750 WP_258413526.1 CPBP family lipoprotein N-acylation protein LnsB -
NW979_RS11985 (NW979_11985) 2459548..2460741 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T254656 WP_000074045.1 NZ_CP102959:c2455565-2455299 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT254656 WP_000587619.1 NZ_CP102959:c2455822-2455565 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References