Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2422765..2422949 Replicon chromosome
Accession NZ_CP102959
Organism Staphylococcus aureus strain 12-G-51

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag NW979_RS11815 Protein ID WP_000482650.1
Coordinates 2422842..2422949 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2422765..2422825 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW979_RS11800 (NW979_11800) 2418295..2418462 - 168 WP_001790576.1 hypothetical protein -
NW979_RS11805 (NW979_11805) 2418693..2420426 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
NW979_RS11810 (NW979_11810) 2420451..2422214 - 1764 Protein_2278 ABC transporter ATP-binding protein -
- 2422765..2422825 + 61 - - Antitoxin
NW979_RS11815 (NW979_11815) 2422842..2422949 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
NW979_RS11820 (NW979_11820) 2423083..2423469 - 387 WP_000779358.1 flippase GtxA -
NW979_RS11825 (NW979_11825) 2423737..2424879 + 1143 WP_001176863.1 glycerate kinase -
NW979_RS11830 (NW979_11830) 2424939..2425598 + 660 WP_000831298.1 membrane protein -
NW979_RS11835 (NW979_11835) 2425780..2426991 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
NW979_RS11840 (NW979_11840) 2427114..2427587 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T254655 WP_000482650.1 NZ_CP102959:c2422949-2422842 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254655 NZ_CP102959:2422765-2422825 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References