Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2397372..2397889 Replicon chromosome
Accession NZ_CP102959
Organism Staphylococcus aureus strain 12-G-51

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW979_RS11680 Protein ID WP_000113262.1
Coordinates 2397372..2397638 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW979_RS11685 Protein ID WP_000584499.1
Coordinates 2397638..2397889 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW979_RS11650 (NW979_11650) 2392799..2393335 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
NW979_RS11655 (NW979_11655) 2393569..2394393 - 825 WP_000594630.1 formate/nitrite transporter family protein -
NW979_RS11660 (NW979_11660) 2394609..2394794 - 186 WP_000230293.1 hypothetical protein -
NW979_RS11665 (NW979_11665) 2394878..2395345 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW979_RS11670 (NW979_11670) 2395531..2397078 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW979_RS11675 (NW979_11675) 2397266..2397337 - 72 WP_223200558.1 hypothetical protein -
NW979_RS11680 (NW979_11680) 2397372..2397638 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW979_RS11685 (NW979_11685) 2397638..2397889 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW979_RS11690 (NW979_11690) 2398052..2398153 - 102 Protein_2254 hypothetical protein -
NW979_RS11695 (NW979_11695) 2398160..2398759 - 600 WP_000162810.1 DsbA family protein -
NW979_RS11700 (NW979_11700) 2398778..2399140 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW979_RS11705 (NW979_11705) 2399395..2400645 + 1251 WP_258413516.1 FemA/FemB family glycyltransferase FmhA -
NW979_RS11710 (NW979_11710) 2400730..2401461 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
NW979_RS11715 (NW979_11715) 2401458..2402177 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254654 WP_000113262.1 NZ_CP102959:c2397638-2397372 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254654 WP_000584499.1 NZ_CP102959:c2397889-2397638 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References