Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2360765..2361282 Replicon chromosome
Accession NZ_CP102958
Organism Staphylococcus aureus strain 15-G-54

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW969_RS11485 Protein ID WP_000113262.1
Coordinates 2360765..2361031 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW969_RS11490 Protein ID WP_000584499.1
Coordinates 2361031..2361282 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW969_RS11455 (NW969_11455) 2356187..2356723 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW969_RS11460 (NW969_11460) 2356956..2357780 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW969_RS11465 (NW969_11465) 2357997..2358179 - 183 WP_000230294.1 hypothetical protein -
NW969_RS11470 (NW969_11470) 2358263..2358730 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW969_RS11475 (NW969_11475) 2358916..2360469 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW969_RS11480 (NW969_11480) 2360653..2360730 - 78 Protein_2212 hypothetical protein -
NW969_RS11485 (NW969_11485) 2360765..2361031 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW969_RS11490 (NW969_11490) 2361031..2361282 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW969_RS11495 (NW969_11495) 2361447..2361548 - 102 WP_031774922.1 hypothetical protein -
NW969_RS11500 (NW969_11500) 2361555..2362154 - 600 WP_000162810.1 DsbA family protein -
NW969_RS11505 (NW969_11505) 2362173..2362535 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW969_RS11510 (NW969_11510) 2362790..2364040 + 1251 WP_072353895.1 FemA/FemB family glycyltransferase FmhA -
NW969_RS11515 (NW969_11515) 2364137..2364868 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW969_RS11520 (NW969_11520) 2364865..2365584 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254647 WP_000113262.1 NZ_CP102958:c2361031-2360765 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254647 WP_000584499.1 NZ_CP102958:c2361282-2361031 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References