Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2377435..2377952 Replicon chromosome
Accession NZ_CP102957
Organism Staphylococcus aureus strain 18-H-62

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW959_RS11665 Protein ID WP_000113262.1
Coordinates 2377435..2377701 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW959_RS11670 Protein ID WP_000584499.1
Coordinates 2377701..2377952 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW959_RS11635 (NW959_11635) 2372862..2373398 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW959_RS11640 (NW959_11640) 2373631..2374455 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW959_RS11645 (NW959_11645) 2374672..2374854 - 183 WP_000230294.1 hypothetical protein -
NW959_RS11650 (NW959_11650) 2374938..2375405 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW959_RS11655 (NW959_11655) 2375591..2377141 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW959_RS11660 (NW959_11660) 2377329..2377400 - 72 WP_223200558.1 hypothetical protein -
NW959_RS11665 (NW959_11665) 2377435..2377701 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW959_RS11670 (NW959_11670) 2377701..2377952 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW959_RS11675 (NW959_11675) 2378117..2378218 - 102 WP_031867537.1 hypothetical protein -
NW959_RS11680 (NW959_11680) 2378225..2378824 - 600 WP_000162810.1 DsbA family protein -
NW959_RS11685 (NW959_11685) 2378843..2379205 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW959_RS11690 (NW959_11690) 2379460..2380710 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
NW959_RS11695 (NW959_11695) 2380807..2381538 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW959_RS11700 (NW959_11700) 2381535..2382254 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254638 WP_000113262.1 NZ_CP102957:c2377701-2377435 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254638 WP_000584499.1 NZ_CP102957:c2377952-2377701 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References