254631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2496294..2496817 Replicon chromosome
Accession NZ_CP102956
Organism Staphylococcus aureus strain 26-G-G

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NW981_RS12335 Protein ID WP_258410238.1
Coordinates 2496294..2496560 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NW981_RS12340 Protein ID WP_000587618.1
Coordinates 2496560..2496817 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW981_RS12315 (NW981_12315) 2491600..2492787 - 1188 WP_000026189.1 MFS transporter -
NW981_RS12320 (NW981_12320) 2493183..2493959 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW981_RS12325 (NW981_12325) 2493952..2494614 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW981_RS12330 (NW981_12330) 2494862..2495938 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW981_RS12335 (NW981_12335) 2496294..2496560 - 267 WP_258410238.1 Txe/YoeB family addiction module toxin Toxin
NW981_RS12340 (NW981_12340) 2496560..2496817 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW981_RS12345 (NW981_12345) 2497175..2497630 + 456 WP_000732090.1 YehR family lipoprotein -
NW981_RS12350 (NW981_12350) 2497798..2499375 - 1578 WP_258410239.1 FMN-binding glutamate synthase family protein -
NW981_RS12355 (NW981_12355) 2499570..2500319 + 750 WP_258410240.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 10.4605

>T254631 WP_258410238.1 NZ_CP102956:c2496560-2496294 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLQPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT254631 WP_000587618.1 NZ_CP102956:c2496817-2496560 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References