Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2439817..2440334 Replicon chromosome
Accession NZ_CP102956
Organism Staphylococcus aureus strain 26-G-G

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW981_RS12060 Protein ID WP_000113262.1
Coordinates 2439817..2440083 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW981_RS12065 Protein ID WP_000584499.1
Coordinates 2440083..2440334 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW981_RS12030 (NW981_12030) 2435242..2435778 - 537 WP_258410226.1 GNAT family N-acetyltransferase -
NW981_RS12035 (NW981_12035) 2436012..2436836 - 825 WP_000594630.1 formate/nitrite transporter family protein -
NW981_RS12040 (NW981_12040) 2437053..2437235 - 183 WP_258410227.1 hypothetical protein -
NW981_RS12045 (NW981_12045) 2437322..2437789 - 468 WP_258410228.1 SRPBCC domain-containing protein -
NW981_RS12050 (NW981_12050) 2437975..2439522 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW981_RS12055 (NW981_12055) 2439711..2439782 - 72 Protein_2328 hypothetical protein -
NW981_RS12060 (NW981_12060) 2439817..2440083 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW981_RS12065 (NW981_12065) 2440083..2440334 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW981_RS12070 (NW981_12070) 2440499..2440579 - 81 WP_223197974.1 hypothetical protein -
NW981_RS12075 (NW981_12075) 2440607..2441206 - 600 WP_000162810.1 DsbA family protein -
NW981_RS12080 (NW981_12080) 2441225..2441587 - 363 WP_258410229.1 DUF4467 domain-containing protein -
NW981_RS12085 (NW981_12085) 2441842..2443092 + 1251 WP_258410230.1 FemA/FemB family glycyltransferase FmhA -
NW981_RS12090 (NW981_12090) 2443177..2443908 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW981_RS12095 (NW981_12095) 2443905..2444624 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254629 WP_000113262.1 NZ_CP102956:c2440083-2439817 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254629 WP_000584499.1 NZ_CP102956:c2440334-2440083 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References