Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2459149..2459672 Replicon chromosome
Accession NZ_CP102955
Organism Staphylococcus aureus strain 28-G-I

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag NW961_RS12120 Protein ID WP_000074043.1
Coordinates 2459149..2459415 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NW961_RS12125 Protein ID WP_000587618.1
Coordinates 2459415..2459672 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW961_RS12100 (NW961_12100) 2454455..2455642 - 1188 WP_000026187.1 MFS transporter -
NW961_RS12105 (NW961_12105) 2456038..2456814 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW961_RS12110 (NW961_12110) 2456807..2457469 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
NW961_RS12115 (NW961_12115) 2457717..2458793 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW961_RS12120 (NW961_12120) 2459149..2459415 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
NW961_RS12125 (NW961_12125) 2459415..2459672 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW961_RS12130 (NW961_12130) 2460031..2460486 + 456 WP_000732091.1 DUF1307 domain-containing protein -
NW961_RS12135 (NW961_12135) 2460654..2462231 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
NW961_RS12140 (NW961_12140) 2462427..2463176 + 750 WP_258415665.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T254624 WP_000074043.1 NZ_CP102955:c2459415-2459149 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT254624 WP_000587618.1 NZ_CP102955:c2459672-2459415 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References