254622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2402542..2403059 Replicon chromosome
Accession NZ_CP102955
Organism Staphylococcus aureus strain 28-G-I

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NW961_RS11845 Protein ID WP_258415660.1
Coordinates 2402542..2402808 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW961_RS11850 Protein ID WP_000584499.1
Coordinates 2402808..2403059 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW961_RS11815 (NW961_11815) 2397958..2398527 + 570 Protein_2279 transposase -
NW961_RS11820 (NW961_11820) 2398729..2399553 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW961_RS11825 (NW961_11825) 2399770..2399952 - 183 WP_000079140.1 hypothetical protein -
NW961_RS11830 (NW961_11830) 2400039..2400506 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW961_RS11835 (NW961_11835) 2400692..2402248 - 1557 WP_049307643.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW961_RS11840 (NW961_11840) 2402436..2402507 - 72 WP_223200558.1 hypothetical protein -
NW961_RS11845 (NW961_11845) 2402542..2402808 - 267 WP_258415660.1 Txe/YoeB family addiction module toxin Toxin
NW961_RS11850 (NW961_11850) 2402808..2403059 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW961_RS11855 (NW961_11855) 2403224..2403325 - 102 Protein_2287 hypothetical protein -
NW961_RS11860 (NW961_11860) 2403332..2403931 - 600 WP_000162810.1 DsbA family protein -
NW961_RS11865 (NW961_11865) 2403950..2404312 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW961_RS11870 (NW961_11870) 2404567..2405817 + 1251 WP_258415661.1 FemA/FemB family glycyltransferase FmhA -
NW961_RS11875 (NW961_11875) 2405914..2406645 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW961_RS11880 (NW961_11880) 2406642..2407361 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2398240..2398557 317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.1013

>T254622 WP_258415660.1 NZ_CP102955:c2402808-2402542 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGASKGIGKPEKLKSNLTGYYSRRINYEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254622 WP_000584499.1 NZ_CP102955:c2403059-2402808 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References