Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2502288..2502811 Replicon chromosome
Accession NZ_CP102954
Organism Staphylococcus aureus strain 30-P-10

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NW951_RS12385 Protein ID WP_258410238.1
Coordinates 2502288..2502554 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NW951_RS12390 Protein ID WP_000587618.1
Coordinates 2502554..2502811 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW951_RS12365 (NW951_12365) 2497594..2498781 - 1188 WP_000026189.1 MFS transporter -
NW951_RS12370 (NW951_12370) 2499177..2499953 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW951_RS12375 (NW951_12375) 2499946..2500608 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW951_RS12380 (NW951_12380) 2500856..2501932 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW951_RS12385 (NW951_12385) 2502288..2502554 - 267 WP_258410238.1 Txe/YoeB family addiction module toxin Toxin
NW951_RS12390 (NW951_12390) 2502554..2502811 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW951_RS12395 (NW951_12395) 2503169..2503624 + 456 WP_000732090.1 YehR family lipoprotein -
NW951_RS12400 (NW951_12400) 2503792..2505369 - 1578 WP_258410239.1 FMN-binding glutamate synthase family protein -
NW951_RS12405 (NW951_12405) 2505564..2506313 + 750 WP_258410240.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 10.4605

>T254615 WP_258410238.1 NZ_CP102954:c2502554-2502288 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLQPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT254615 WP_000587618.1 NZ_CP102954:c2502811-2502554 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References