254613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2445600..2446117 Replicon chromosome
Accession NZ_CP102954
Organism Staphylococcus aureus strain 30-P-10

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW951_RS12110 Protein ID WP_000113262.1
Coordinates 2445600..2445866 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW951_RS12115 Protein ID WP_000584499.1
Coordinates 2445866..2446117 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW951_RS12080 (NW951_12080) 2441025..2441561 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW951_RS12085 (NW951_12085) 2441794..2442618 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW951_RS12090 (NW951_12090) 2442835..2443017 - 183 WP_000230294.1 hypothetical protein -
NW951_RS12095 (NW951_12095) 2443101..2443568 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW951_RS12100 (NW951_12100) 2443754..2445304 - 1551 WP_258413132.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW951_RS12105 (NW951_12105) 2445488..2445565 - 78 Protein_2337 hypothetical protein -
NW951_RS12110 (NW951_12110) 2445600..2445866 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW951_RS12115 (NW951_12115) 2445866..2446117 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW951_RS12120 (NW951_12120) 2446282..2446362 - 81 WP_223197974.1 hypothetical protein -
NW951_RS12125 (NW951_12125) 2446390..2446989 - 600 WP_000162810.1 DsbA family protein -
NW951_RS12130 (NW951_12130) 2447008..2447370 - 363 WP_258410229.1 DUF4467 domain-containing protein -
NW951_RS12135 (NW951_12135) 2447625..2448875 + 1251 WP_258410230.1 FemA/FemB family glycyltransferase FmhA -
NW951_RS12140 (NW951_12140) 2448960..2449691 - 732 WP_258413133.1 amino acid ABC transporter ATP-binding protein -
NW951_RS12145 (NW951_12145) 2449688..2450407 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254613 WP_000113262.1 NZ_CP102954:c2445866-2445600 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254613 WP_000584499.1 NZ_CP102954:c2446117-2445866 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References