254603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2418119..2418636 Replicon chromosome
Accession NZ_CP102953
Organism Staphylococcus aureus strain 32-T-13

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW977_RS11975 Protein ID WP_000113262.1
Coordinates 2418119..2418385 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW977_RS11980 Protein ID WP_000584499.1
Coordinates 2418385..2418636 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW977_RS11945 (NW977_11945) 2413544..2414080 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW977_RS11950 (NW977_11950) 2414314..2415138 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW977_RS11955 (NW977_11955) 2415355..2415537 - 183 WP_000079140.1 hypothetical protein -
NW977_RS11960 (NW977_11960) 2415624..2416091 - 468 WP_258410228.1 SRPBCC domain-containing protein -
NW977_RS11965 (NW977_11965) 2416277..2417824 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW977_RS11970 (NW977_11970) 2418013..2418084 - 72 Protein_2310 hypothetical protein -
NW977_RS11975 (NW977_11975) 2418119..2418385 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW977_RS11980 (NW977_11980) 2418385..2418636 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW977_RS11985 (NW977_11985) 2418801..2418881 - 81 WP_223197974.1 hypothetical protein -
NW977_RS11990 (NW977_11990) 2418909..2419508 - 600 WP_000162810.1 DsbA family protein -
NW977_RS11995 (NW977_11995) 2419527..2419889 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW977_RS12000 (NW977_12000) 2420144..2421394 + 1251 WP_258412659.1 FemA/FemB family glycyltransferase FmhA -
NW977_RS12005 (NW977_12005) 2421491..2422222 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW977_RS12010 (NW977_12010) 2422219..2422938 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254603 WP_000113262.1 NZ_CP102953:c2418385-2418119 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254603 WP_000584499.1 NZ_CP102953:c2418636-2418385 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References