Detailed information of TA system TA254601

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2294789..2295368
• Replicon: chromosome
• Accession: NZ_CP102953
• Organism: Staphylococcus aureus strain 32-T-13

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW977_RS11370
• Protein ID: WP_258411822.1
• Coordinates: 2295135..2295368 (-)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2294789..2295152 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW977_RS11330 (NW977_11330)	2290644..2292587	-	1944	WP_258414929.1	AAA family ATPase	-
NW977_RS11335 (NW977_11335)	2292596..2292859	-	264	WP_001205732.1	hypothetical protein	-
NW977_RS11340 (NW977_11340)	2292868..2293128	-	261	WP_258411816.1	DUF1108 family protein	-
NW977_RS11345 (NW977_11345)	2293133..2293435	-	303	WP_258411817.1	DUF2482 family protein	-
NW977_RS11350 (NW977_11350)	2293527..2293688	-	162	WP_258411818.1	DUF1270 domain-containing protein	-
NW977_RS11355 (NW977_11355)	2293701..2293964	-	264	WP_258411819.1	helix-turn-helix domain-containing protein	-
NW977_RS11360 (NW977_11360)	2293979..2294734	-	756	WP_258411820.1	phage regulatory protein/antirepressor Ant	-
-	2294789..2295152	+	364	-	-	Antitoxin
NW977_RS11370 (NW977_11370)	2295135..2295368	-	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
NW977_RS11375 (NW977_11375)	2295411..2295728	-	318	WP_258411823.1	hypothetical protein	-
NW977_RS11380 (NW977_11380)	2295744..2295953	-	210	WP_047447803.1	helix-turn-helix transcriptional regulator	-
NW977_RS11385 (NW977_11385)	2296150..2296779	+	630	WP_258411824.1	XRE family transcriptional regulator	-
NW977_RS11390 (NW977_11390)	2296794..2297684	+	891	WP_258411825.1	exonuclease domain-containing protein	-
NW977_RS11395 (NW977_11395)	2297715..2297861	+	147	WP_078064955.1	hypothetical protein	-
NW977_RS11400 (NW977_11400)	2297858..2298472	-	615	WP_258414930.1	ATPase	-
NW977_RS11405 (NW977_11405)	2298597..2299802	+	1206	WP_258411827.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2257701..2311494	53793

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254601 WP_258411822.1 NZ_CP102953:c2295368-2295135 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254601 NZ_CP102953:2294789-2295152 [Staphylococcus aureus]
ATGCCCTTGATATCCGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAGTTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTCCATGGTGTGCTTGCAGAC
AACACTATTTATCATGTGACAATATCGGATAAGACTATTGTTTATTTCGAAAATAAGTTTAAAAACAATTTAAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin