Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2471295..2471818 Replicon chromosome
Accession NZ_CP102952
Organism Staphylococcus aureus strain 39-B-49

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NW967_RS12155 Protein ID WP_258411356.1
Coordinates 2471295..2471561 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag NW967_RS12160 Protein ID WP_000587619.1
Coordinates 2471561..2471818 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW967_RS12135 (NW967_12135) 2466603..2467790 - 1188 WP_000026189.1 MFS transporter -
NW967_RS12140 (NW967_12140) 2468184..2468960 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW967_RS12145 (NW967_12145) 2468953..2469615 - 663 WP_258411355.1 ATP-binding cassette domain-containing protein -
NW967_RS12150 (NW967_12150) 2469863..2470939 - 1077 WP_001076671.1 M42 family metallopeptidase -
NW967_RS12155 (NW967_12155) 2471295..2471561 - 267 WP_258411356.1 Txe/YoeB family addiction module toxin Toxin
NW967_RS12160 (NW967_12160) 2471561..2471818 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW967_RS12165 (NW967_12165) 2472176..2472631 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NW967_RS12170 (NW967_12170) 2472799..2474376 - 1578 WP_258411357.1 FMN-binding glutamate synthase family protein -
NW967_RS12175 (NW967_12175) 2474573..2475322 + 750 WP_258411358.1 CPBP family lipoprotein N-acylation protein LnsB -
NW967_RS12180 (NW967_12180) 2475546..2476739 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.31 Da        Isoelectric Point: 10.1383

>T254594 WP_258411356.1 NZ_CP102952:c2471561-2471295 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT254594 WP_000587619.1 NZ_CP102952:c2471818-2471561 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References