Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2413398..2413915 Replicon chromosome
Accession NZ_CP102952
Organism Staphylococcus aureus strain 39-B-49

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW967_RS11875 Protein ID WP_000113262.1
Coordinates 2413398..2413664 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW967_RS11880 Protein ID WP_000584499.1
Coordinates 2413664..2413915 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW967_RS11845 (NW967_11845) 2408903..2409388 - 486 WP_000093392.1 IS200/IS605 family transposase -
NW967_RS11850 (NW967_11850) 2409597..2410421 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW967_RS11855 (NW967_11855) 2410638..2410820 - 183 WP_000230294.1 hypothetical protein -
NW967_RS11860 (NW967_11860) 2410904..2411371 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW967_RS11865 (NW967_11865) 2411557..2413104 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW967_RS11870 (NW967_11870) 2413292..2413363 - 72 WP_223200558.1 hypothetical protein -
NW967_RS11875 (NW967_11875) 2413398..2413664 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW967_RS11880 (NW967_11880) 2413664..2413915 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW967_RS11885 (NW967_11885) 2414080..2414160 - 81 WP_223197974.1 hypothetical protein -
NW967_RS11890 (NW967_11890) 2414188..2414787 - 600 WP_258411330.1 DsbA family protein -
NW967_RS11895 (NW967_11895) 2414806..2415168 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW967_RS11900 (NW967_11900) 2415423..2416673 + 1251 WP_258411331.1 FemA/FemB family glycyltransferase FmhA -
NW967_RS11905 (NW967_11905) 2416770..2417501 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW967_RS11910 (NW967_11910) 2417498..2418217 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2408903..2409388 485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254592 WP_000113262.1 NZ_CP102952:c2413664-2413398 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254592 WP_000584499.1 NZ_CP102952:c2413915-2413664 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References