254571

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4820552..4821154 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag NW339_RS23580 Protein ID WP_000897302.1
Coordinates 4820843..4821154 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NW339_RS23575 Protein ID WP_000356397.1
Coordinates 4820552..4820842 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS23545 (4815859) 4815859..4816788 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
NW339_RS23550 (4816970) 4816970..4817212 - 243 WP_001068514.1 CopG family transcriptional regulator -
NW339_RS23555 (4817502) 4817502..4818350 + 849 WP_001038650.1 hypothetical protein -
NW339_RS23560 (4818375) 4818375..4819115 + 741 WP_000608806.1 hypothetical protein -
NW339_RS23565 (4819300) 4819300..4819518 - 219 WP_001251293.1 CopG family transcriptional regulator -
NW339_RS23570 (4819915) 4819915..4820193 - 279 WP_001296612.1 hypothetical protein -
NW339_RS23575 (4820552) 4820552..4820842 - 291 WP_000356397.1 NadS family protein Antitoxin
NW339_RS23580 (4820843) 4820843..4821154 - 312 WP_000897302.1 hypothetical protein Toxin
NW339_RS23585 (4821383) 4821383..4822291 + 909 WP_001385591.1 alpha/beta hydrolase -
NW339_RS23590 (4822355) 4822355..4823296 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NW339_RS23595 (4823341) 4823341..4823778 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
NW339_RS23600 (4823775) 4823775..4824647 - 873 WP_000920762.1 virulence factor BrkB family protein -
NW339_RS23605 (4824641) 4824641..4825240 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T254571 WP_000897302.1 NZ_CP102947:c4821154-4820843 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT254571 WP_000356397.1 NZ_CP102947:c4820842-4820552 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References