254561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3602476..3603155 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag NW339_RS17805 Protein ID WP_000057523.1
Coordinates 3602853..3603155 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag NW339_RS17800 Protein ID WP_000806442.1
Coordinates 3602476..3602817 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS17790 (3598720) 3598720..3599652 - 933 WP_000883041.1 glutaminase A -
NW339_RS17795 (3599914) 3599914..3602418 + 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
NW339_RS17800 (3602476) 3602476..3602817 - 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
NW339_RS17805 (3602853) 3602853..3603155 - 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW339_RS17810 (3603288) 3603288..3604082 + 795 WP_000365147.1 TraB/GumN family protein -
NW339_RS17815 (3604286) 3604286..3604765 + 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
NW339_RS17820 (3604933) 3604933..3605589 + 657 WP_015674862.1 hypothetical protein -
NW339_RS17825 (3605586) 3605586..3606089 + 504 WP_000667000.1 hypothetical protein -
NW339_RS17830 (3606127) 3606127..3607779 - 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T254561 WP_000057523.1 NZ_CP102947:c3603155-3602853 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT254561 WP_000806442.1 NZ_CP102947:c3602817-3602476 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References