254554

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1910693..1911195 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag NW339_RS09075 Protein ID WP_000767819.1
Coordinates 1910941..1911195 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag NW339_RS09070 Protein ID WP_001259253.1
Coordinates 1910693..1910944 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS09045 (1905871) 1905871..1906938 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NW339_RS09050 (1906938) 1906938..1908008 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
NW339_RS09055 (1908005) 1908005..1909309 - 1305 WP_001296211.1 histidinol dehydrogenase -
NW339_RS09060 (1909315) 1909315..1910214 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NW339_RS09065 (1910360) 1910360..1910410 - 51 WP_001364200.1 his operon leader peptide -
NW339_RS09070 (1910693) 1910693..1910944 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NW339_RS09075 (1910941) 1910941..1911195 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NW339_RS09080 (1911278) 1911278..1912102 + 825 WP_000754737.1 SDR family oxidoreductase -
NW339_RS09085 (1912148) 1912148..1913077 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NW339_RS09090 (1913292) 1913292..1913354 + 63 WP_010723108.1 membrane protein YoeI -
NW339_RS09095 (1913344) 1913344..1914702 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
NW339_RS09100 (1914919) 1914919..1915377 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1914919..1915377 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T254554 WP_000767819.1 NZ_CP102947:1910941-1911195 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT254554 WP_001259253.1 NZ_CP102947:1910693-1910944 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References