254550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 602601..603400 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NW339_RS02975 Protein ID WP_000347251.1
Coordinates 602601..603065 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NW339_RS02980 Protein ID WP_001296435.1
Coordinates 603065..603400 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS02945 (597602) 597602..598036 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NW339_RS02950 (598054) 598054..598932 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NW339_RS02955 (598922) 598922..599701 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NW339_RS02960 (599712) 599712..600185 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NW339_RS02965 (600208) 600208..601488 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
NW339_RS02970 (601737) 601737..602546 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NW339_RS02975 (602601) 602601..603065 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NW339_RS02980 (603065) 603065..603400 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NW339_RS02985 (603549) 603549..605120 - 1572 WP_001273763.1 galactarate dehydratase -
NW339_RS02990 (605495) 605495..606829 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NW339_RS02995 (606845) 606845..607615 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T254550 WP_000347251.1 NZ_CP102947:c603065-602601 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT254550 WP_001296435.1 NZ_CP102947:c603400-603065 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References