Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5484464..5485059 Replicon chromosome
Accession NZ_CP102946
Organism Pseudomonas aeruginosa strain SCAID WND1-2022 (148)

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NW341_RS25540 Protein ID WP_003113526.1
Coordinates 5484781..5485059 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NW341_RS25535 Protein ID WP_003113527.1
Coordinates 5484464..5484769 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW341_RS25500 (NW341_25500) 5479604..5480452 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
NW341_RS25510 (NW341_25510) 5480619..5481560 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
NW341_RS25515 (NW341_25515) 5481677..5482291 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
NW341_RS25520 (NW341_25520) 5482333..5482917 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
NW341_RS25525 (NW341_25525) 5482958..5484058 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
NW341_RS25535 (NW341_25535) 5484464..5484769 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
NW341_RS25540 (NW341_25540) 5484781..5485059 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW341_RS25545 (NW341_25545) 5485112..5485240 - 129 Protein_5047 integrase -
NW341_RS25550 (NW341_25550) 5485388..5487616 + 2229 WP_033876905.1 TonB-dependent receptor -
NW341_RS25555 (NW341_25555) 5487686..5488333 - 648 WP_003095021.1 carbonate dehydratase -
NW341_RS25560 (NW341_25560) 5488395..5489633 - 1239 WP_033876906.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T254548 WP_003113526.1 NZ_CP102946:c5485059-5484781 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT254548 WP_003113527.1 NZ_CP102946:c5484769-5484464 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References