254546

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4766774..4767455 Replicon chromosome
Accession NZ_CP102946
Organism Pseudomonas aeruginosa strain SCAID WND1-2022 (148)

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag NW341_RS22155 Protein ID WP_003111825.1
Coordinates 4767090..4767455 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag NW341_RS22150 Protein ID WP_003159602.1
Coordinates 4766774..4767097 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW341_RS22120 (NW341_22120) 4762231..4763109 + 879 WP_003163191.1 hypothetical protein -
NW341_RS22130 (NW341_22130) 4763739..4765448 + 1710 WP_003085674.1 TIGR04141 family sporadically distributed protein -
NW341_RS22135 (NW341_22135) 4765434..4766152 - 719 Protein_4379 tyrosine-type recombinase/integrase -
NW341_RS22140 (NW341_22140) 4766152..4766544 - 393 Protein_4380 hypothetical protein -
NW341_RS22145 (NW341_22145) 4766539..4766658 + 120 Protein_4381 IS5/IS1182 family transposase -
NW341_RS22150 (NW341_22150) 4766774..4767097 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
NW341_RS22155 (NW341_22155) 4767090..4767455 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW341_RS22160 (NW341_22160) 4767746..4767920 - 175 Protein_4384 hypothetical protein -
NW341_RS22165 (NW341_22165) 4768127..4768399 + 273 WP_031805311.1 hypothetical protein -
NW341_RS22170 (NW341_22170) 4768430..4768855 - 426 WP_003140891.1 VOC family protein -
NW341_RS22175 (NW341_22175) 4768956..4769840 + 885 WP_031805310.1 LysR substrate-binding domain-containing protein -
NW341_RS22180 (NW341_22180) 4769813..4770766 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
NW341_RS22185 (NW341_22185) 4770987..4771421 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T254546 WP_003111825.1 NZ_CP102946:c4767455-4767090 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT254546 WP_003159602.1 NZ_CP102946:c4767097-4766774 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References