Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2021132..2021546 | Replicon | chromosome |
| Accession | NZ_CP102945 | ||
| Organism | Staphylococcus aureus strain SCAID OTT1-2022 (150) | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | NW338_RS10055 | Protein ID | WP_001065046.1 |
| Coordinates | 2021295..2021546 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NW338_RS10050 | Protein ID | WP_000028424.1 |
| Coordinates | 2021132..2021305 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NW338_RS09990 (2016696) | 2016696..2017040 | - | 345 | WP_000817289.1 | HNH endonuclease | - |
| NW338_RS09995 (2017056) | 2017056..2017508 | - | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| NW338_RS10000 (2017623) | 2017623..2018093 | - | 471 | WP_000282758.1 | hypothetical protein | - |
| NW338_RS10005 (2018116) | 2018116..2018316 | - | 201 | WP_000265041.1 | DUF1514 family protein | - |
| NW338_RS10010 (2018316) | 2018316..2018966 | - | 651 | WP_001005262.1 | hypothetical protein | - |
| NW338_RS10015 (2019125) | 2019125..2019274 | - | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| NW338_RS10020 (2019271) | 2019271..2019657 | - | 387 | WP_000592201.1 | hypothetical protein | - |
| NW338_RS10025 (2019654) | 2019654..2019860 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| NW338_RS10030 (2019857) | 2019857..2020102 | - | 246 | WP_001282074.1 | hypothetical protein | - |
| NW338_RS10035 (2020139) | 2020139..2020672 | - | 534 | WP_001061838.1 | dUTPase | - |
| NW338_RS10040 (2020687) | 2020687..2020848 | - | 162 | WP_164492492.1 | hypothetical protein | - |
| NW338_RS10045 (2020849) | 2020849..2021103 | - | 255 | WP_223289771.1 | hypothetical protein | - |
| NW338_RS10050 (2021132) | 2021132..2021305 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| NW338_RS10055 (2021295) | 2021295..2021546 | - | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| NW338_RS10060 (2021561) | 2021561..2021803 | - | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| NW338_RS10065 (2021807) | 2021807..2022175 | - | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| NW338_RS10070 (2022188) | 2022188..2022643 | - | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| NW338_RS10075 (2022652) | 2022652..2022870 | - | 219 | WP_000338527.1 | hypothetical protein | - |
| NW338_RS10080 (2022877) | 2022877..2023770 | - | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| NW338_RS10085 (2023800) | 2023800..2024270 | - | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| NW338_RS10090 (2024271) | 2024271..2024888 | - | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| NW338_RS10095 (2024969) | 2024969..2025889 | - | 921 | WP_000138475.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | hlb / groEL / hld | 1995998..2074348 | 78350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|