Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5763167..5763762 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NW342_RS27085 Protein ID WP_003113526.1
Coordinates 5763484..5763762 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag NW342_RS27080 Protein ID WP_003111575.1
Coordinates 5763167..5763472 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS27045 (NW342_27045) 5758307..5759155 + 849 WP_031686602.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
NW342_RS27055 (NW342_27055) 5759322..5760263 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
NW342_RS27060 (NW342_27060) 5760380..5760994 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
NW342_RS27065 (NW342_27065) 5761036..5761620 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
NW342_RS27070 (NW342_27070) 5761661..5762761 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
NW342_RS27080 (NW342_27080) 5763167..5763472 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
NW342_RS27085 (NW342_27085) 5763484..5763762 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW342_RS27090 (NW342_27090) 5763815..5763943 - 129 Protein_5355 integrase -
NW342_RS27095 (NW342_27095) 5764091..5766319 + 2229 WP_033991161.1 TonB-dependent receptor -
NW342_RS27100 (NW342_27100) 5766390..5767037 - 648 WP_003095021.1 carbonate dehydratase -
NW342_RS27105 (NW342_27105) 5767099..5768337 - 1239 WP_031686604.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T254529 WP_003113526.1 NZ_CP102944:c5763762-5763484 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT254529 WP_003111575.1 NZ_CP102944:c5763472-5763167 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References