Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2447..3032 Replicon plasmid unnamed3
Accession NZ_CP102937
Organism Acinetobacter sp. AOR07_HL

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag MKL45_RS19340 Protein ID WP_000897309.1
Coordinates 2447..2767 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MKL45_RS19345 Protein ID WP_000369780.1
Coordinates 2760..3032 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKL45_RS19315 (MKL45_19320) 126..392 + 267 WP_188200041.1 mobilization protein -
MKL45_RS19320 (MKL45_19325) 410..1129 + 720 WP_001218546.1 hypothetical protein -
MKL45_RS19325 (MKL45_19330) 1455..1670 + 216 WP_000071892.1 cold-shock protein -
MKL45_RS19330 (MKL45_19335) 1769..1996 + 228 WP_000921865.1 hypothetical protein -
MKL45_RS19335 (MKL45_19340) 2063..2260 + 198 WP_000476222.1 hypothetical protein -
MKL45_RS19340 (MKL45_19345) 2447..2767 + 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKL45_RS19345 (MKL45_19350) 2760..3032 + 273 WP_000369780.1 NadS family protein Antitoxin
MKL45_RS19350 (MKL45_19355) 3650..4168 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MKL45_RS19355 (MKL45_19360) 4356..4583 - 228 WP_004812234.1 hypothetical protein -
MKL45_RS19360 (MKL45_19365) 4971..5495 - 525 WP_034684955.1 plasmid replication DNA-binding protein -
MKL45_RS19365 (MKL45_19370) 5574..6503 - 930 WP_034684953.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8571 8571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T254506 WP_000897309.1 NZ_CP102937:2447-2767 [Acinetobacter sp. AOR07_HL]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10122.63 Da        Isoelectric Point: 8.6582

>AT254506 WP_000369780.1 NZ_CP102937:2760-3032 [Acinetobacter sp. AOR07_HL]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure

References