Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3577205..3577862 Replicon chromosome
Accession NZ_CP102932
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag NWV12_RS16955 Protein ID WP_033146338.1
Coordinates 3577205..3577504 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag NWV12_RS16960 Protein ID WP_033146339.1
Coordinates 3577515..3577862 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWV12_RS16945 (NWV12_16945) 3573575..3575773 + 2199 WP_048979782.1 type I secretion system permease/ATPase -
NWV12_RS16950 (NWV12_16950) 3575784..3576953 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
NWV12_RS16955 (NWV12_16955) 3577205..3577504 + 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWV12_RS16960 (NWV12_16960) 3577515..3577862 + 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
NWV12_RS16965 (NWV12_16965) 3577907..3578332 + 426 WP_048979783.1 nucleoside triphosphatase NudI -
NWV12_RS16970 (NWV12_16970) 3578335..3578844 - 510 WP_048979784.1 hypothetical protein -
NWV12_RS16975 (NWV12_16975) 3578929..3580110 - 1182 WP_048979785.1 PLP-dependent aminotransferase family protein -
NWV12_RS16980 (NWV12_16980) 3580131..3581018 - 888 WP_048979786.1 LysR family transcriptional regulator -
NWV12_RS16985 (NWV12_16985) 3581116..3581718 + 603 WP_048979787.1 short chain dehydrogenase -
NWV12_RS16990 (NWV12_16990) 3581712..3582446 - 735 WP_048979788.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T254496 WP_033146338.1 NZ_CP102932:3577205-3577504 [Enterobacter sp. Crenshaw]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT254496 WP_033146339.1 NZ_CP102932:3577515-3577862 [Enterobacter sp. Crenshaw]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References