Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2957733..2958393 Replicon chromosome
Accession NZ_CP102932
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name higB Uniprot ID A0A808IFD9
Locus tag NWV12_RS14195 Protein ID WP_048980127.1
Coordinates 2958040..2958393 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag NWV12_RS14190 Protein ID WP_029741460.1
Coordinates 2957733..2958035 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWV12_RS14170 (NWV12_14170) 2953710..2955899 + 2190 WP_045356712.1 TonB-dependent siderophore receptor -
NWV12_RS14180 (NWV12_14180) 2956194..2956595 - 402 WP_048980122.1 RidA family protein -
NWV12_RS14185 (NWV12_14185) 2956737..2957657 + 921 WP_048980124.1 LysR family transcriptional regulator -
NWV12_RS14190 (NWV12_14190) 2957733..2958035 - 303 WP_029741460.1 XRE family transcriptional regulator Antitoxin
NWV12_RS14195 (NWV12_14195) 2958040..2958393 - 354 WP_048980127.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWV12_RS14200 (NWV12_14200) 2958571..2959464 - 894 WP_048980130.1 LysR substrate-binding domain-containing protein -
NWV12_RS14205 (NWV12_14205) 2959638..2960243 + 606 WP_048980132.1 glutathione S-transferase family protein -
NWV12_RS14210 (NWV12_14210) 2960287..2961237 - 951 WP_023336219.1 HTH-type transcriptional regulator Cbl -
NWV12_RS14215 (NWV12_14215) 2961334..2962251 - 918 WP_033145933.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13599.44 Da        Isoelectric Point: 8.9620

>T254495 WP_048980127.1 NZ_CP102932:c2958393-2958040 [Enterobacter sp. Crenshaw]
VWAINTTDRFDRWFTSLDDTDRASVLAALLVLREKGPGLSRPYADTLKGSRYSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLDRLKERE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT254495 WP_029741460.1 NZ_CP102932:c2958035-2957733 [Enterobacter sp. Crenshaw]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IFD9

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MX79

References