Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3833778..3834375 Replicon chromosome
Accession NZ_CP102921
Organism Klebsiella quasipneumoniae strain K18-45

Toxin (Protein)


Gene name higB Uniprot ID A0A3T0QUS6
Locus tag NWF33_RS18875 Protein ID WP_017899012.1
Coordinates 3834058..3834375 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T0QUV3
Locus tag NWF33_RS18870 Protein ID WP_017899013.1
Coordinates 3833778..3834065 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWF33_RS18840 (3829865) 3829865..3830113 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NWF33_RS18845 (3830131) 3830131..3830472 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
NWF33_RS18850 (3830503) 3830503..3831618 - 1116 WP_025999133.1 MBL fold metallo-hydrolase -
NWF33_RS18855 (3831798) 3831798..3832379 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
NWF33_RS18860 (3832379) 3832379..3832747 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
NWF33_RS18865 (3832867) 3832867..3833520 + 654 WP_004202485.1 oxygen-insensitive NAD(P)H nitroreductase -
NWF33_RS18870 (3833778) 3833778..3834065 - 288 WP_017899013.1 helix-turn-helix transcriptional regulator Antitoxin
NWF33_RS18875 (3834058) 3834058..3834375 - 318 WP_017899012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWF33_RS18880 (3834560) 3834560..3835603 - 1044 WP_017899011.1 hypothetical protein -
NWF33_RS18885 (3836136) 3836136..3837005 - 870 WP_017900842.1 helix-turn-helix transcriptional regulator -
NWF33_RS18890 (3837114) 3837114..3838541 + 1428 WP_017900841.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12185.52 Da        Isoelectric Point: 11.2767

>T254456 WP_017899012.1 NZ_CP102921:c3834375-3834058 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 10.2213

>AT254456 WP_017899013.1 NZ_CP102921:c3834065-3833778 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0QUS6

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0QUV3

References