Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3878487..3879084 Replicon chromosome
Accession NZ_CP102898
Organism Klebsiella quasipneumoniae strain KW1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NWT83_RS19040 Protein ID WP_049013659.1
Coordinates 3878767..3879084 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NWT83_RS19035 Protein ID WP_049013658.1
Coordinates 3878487..3878774 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT83_RS19005 (3874675) 3874675..3874923 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NWT83_RS19010 (3874941) 3874941..3875282 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
NWT83_RS19015 (3875313) 3875313..3876428 - 1116 WP_074442613.1 MBL fold metallo-hydrolase -
NWT83_RS19020 (3876608) 3876608..3877192 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
NWT83_RS19025 (3877189) 3877189..3877557 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
NWT83_RS19030 (3877677) 3877677..3878330 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
NWT83_RS19035 (3878487) 3878487..3878774 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
NWT83_RS19040 (3878767) 3878767..3879084 - 318 WP_049013659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT83_RS19045 (3879269) 3879269..3880312 - 1044 WP_065882587.1 DUF2157 domain-containing protein -
NWT83_RS19050 (3880828) 3880828..3881694 - 867 WP_023288725.1 helix-turn-helix transcriptional regulator -
NWT83_RS19055 (3881803) 3881803..3883230 + 1428 WP_048296961.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12102.38 Da        Isoelectric Point: 11.2767

>T254437 WP_049013659.1 NZ_CP102898:c3879084-3878767 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT254437 WP_049013658.1 NZ_CP102898:c3878774-3878487 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References