Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 15226..15953 | Replicon | plasmid pKA1-1 |
| Accession | NZ_CP102894 | ||
| Organism | Klebsiella quasipneumoniae strain KA1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | NWT75_RS25365 | Protein ID | WP_011251285.1 |
| Coordinates | 15226..15537 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NWT75_RS25370 | Protein ID | WP_011251286.1 |
| Coordinates | 15534..15953 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWT75_RS25335 (NWT75_25335) | 11183..11620 | - | 438 | WP_071444170.1 | hypothetical protein | - |
| NWT75_RS25340 (NWT75_25340) | 11664..12632 | + | 969 | WP_258336593.1 | IS5-like element IS903B family transposase | - |
| NWT75_RS25345 (NWT75_25345) | 12690..13739 | - | 1050 | Protein_14 | IS66 family transposase | - |
| NWT75_RS25350 (NWT75_25350) | 13788..14135 | - | 348 | WP_094320106.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| NWT75_RS25355 (NWT75_25355) | 14132..14470 | - | 339 | WP_023288266.1 | transposase | - |
| NWT75_RS25360 (NWT75_25360) | 14584..15021 | + | 438 | Protein_17 | DDE-type integrase/transposase/recombinase | - |
| NWT75_RS25365 (NWT75_25365) | 15226..15537 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NWT75_RS25370 (NWT75_25370) | 15534..15953 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NWT75_RS25375 (NWT75_25375) | 16100..17068 | + | 969 | WP_258336594.1 | IS5 family transposase | - |
| NWT75_RS25380 (NWT75_25380) | 17265..18632 | - | 1368 | WP_258336595.1 | formimidoylglutamate deiminase | - |
| NWT75_RS25385 (NWT75_25385) | 18735..19496 | + | 762 | WP_017900871.1 | histidine utilization repressor | - |
| NWT75_RS25390 (NWT75_25390) | 19493..20050 | + | 558 | WP_017900872.1 | HutD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..184774 | 184774 | |
| - | inside | IScluster/Tn | - | - | 11664..17068 | 5404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T254426 WP_011251285.1 NZ_CP102894:15226-15537 [Klebsiella quasipneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT254426 WP_011251286.1 NZ_CP102894:15534-15953 [Klebsiella quasipneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|