Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 348106..348752 Replicon chromosome
Accession NZ_CP102891
Organism Klebsiella pneumoniae strain KW3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NWT73_RS01610 Protein ID WP_023288046.1
Coordinates 348106..348453 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NWT73_RS01615 Protein ID WP_002920557.1
Coordinates 348453..348752 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT73_RS01600 (NWT73_01600) 344032..345465 + 1434 WP_002920564.1 glycogen synthase GlgA -
NWT73_RS01605 (NWT73_01605) 345483..347930 + 2448 WP_002920561.1 glycogen phosphorylase -
NWT73_RS01610 (NWT73_01610) 348106..348453 + 348 WP_023288046.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT73_RS01615 (NWT73_01615) 348453..348752 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NWT73_RS01620 (NWT73_01620) 348815..350323 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NWT73_RS01625 (NWT73_01625) 350528..350857 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NWT73_RS01630 (NWT73_01630) 350908..351738 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NWT73_RS01635 (NWT73_01635) 351788..352546 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.59 Da        Isoelectric Point: 6.7210

>T254404 WP_023288046.1 NZ_CP102891:348106-348453 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKGSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT254404 WP_002920557.1 NZ_CP102891:348453-348752 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References