Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 730641..731416 Replicon chromosome
Accession NZ_CP102883
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M2890_RS03615 Protein ID WP_004150910.1
Coordinates 730931..731416 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M2890_RS03610 Protein ID WP_004150912.1
Coordinates 730641..730934 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS03590 (725849) 725849..726451 - 603 WP_002916735.1 short chain dehydrogenase -
M2890_RS03595 (726549) 726549..727460 + 912 WP_004188550.1 LysR family transcriptional regulator -
M2890_RS03600 (727461) 727461..728609 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M2890_RS03605 (728620) 728620..729996 - 1377 WP_004217775.1 cystathionine beta-synthase -
M2890_RS03610 (730641) 730641..730934 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M2890_RS03615 (730931) 730931..731416 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M2890_RS03620 (732120) 732120..732713 + 594 WP_004188553.1 hypothetical protein -
M2890_RS03625 (732810) 732810..733026 + 217 Protein_712 transposase -
M2890_RS03630 (733632) 733632..734504 + 873 WP_004188557.1 ParA family protein -
M2890_RS03635 (734504) 734504..734887 + 384 WP_004150906.1 hypothetical protein -
M2890_RS03640 (734880) 734880..736247 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 732810..732962 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T254371 WP_004150910.1 NZ_CP102883:730931-731416 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT254371 WP_004150912.1 NZ_CP102883:730641-730934 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References