Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 69387..70114 | Replicon | plasmid pKA2-1 |
| Accession | NZ_CP102870 | ||
| Organism | Klebsiella pneumoniae strain KA2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | NWT85_RS26140 | Protein ID | WP_011251285.1 |
| Coordinates | 69387..69698 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NWT85_RS26145 | Protein ID | WP_011251286.1 |
| Coordinates | 69695..70114 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWT85_RS26115 (NWT85_26115) | 66104..66283 | - | 180 | Protein_71 | IS5/IS1182 family transposase | - |
| NWT85_RS26120 (NWT85_26120) | 66323..67861 | - | 1539 | WP_017901237.1 | IS66 family transposase | - |
| NWT85_RS26125 (NWT85_26125) | 67910..68257 | - | 348 | WP_032430752.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| NWT85_RS26130 (NWT85_26130) | 68254..68631 | - | 378 | WP_004118218.1 | transposase | - |
| NWT85_RS26135 (NWT85_26135) | 68745..69182 | + | 438 | Protein_75 | DDE-type integrase/transposase/recombinase | - |
| NWT85_RS26140 (NWT85_26140) | 69387..69698 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NWT85_RS26145 (NWT85_26145) | 69695..70114 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NWT85_RS26150 (NWT85_26150) | 70184..70597 | + | 414 | WP_017901337.1 | hypothetical protein | - |
| NWT85_RS26155 (NWT85_26155) | 70643..71611 | - | 969 | WP_258335056.1 | IS5-like element IS903B family transposase | - |
| NWT85_RS26160 (NWT85_26160) | 71715..71981 | + | 267 | WP_017900868.1 | hypothetical protein | - |
| NWT85_RS26165 (NWT85_26165) | 72095..72630 | - | 536 | Protein_81 | transposase | - |
| NWT85_RS26170 (NWT85_26170) | 73155..74522 | - | 1368 | WP_017900870.1 | formimidoylglutamate deiminase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | dfrA12 / aadA2 / qacE / sul1 / mph(A) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / tet(A) / mph(E) / msr(E) / armA / blaDHA-1 / qnrB4 / blaTEM-1B / aac(3)-IId | - | 1..257713 | 257713 | |
| - | inside | IScluster/Tn | - | - | 63801..72489 | 8688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T254342 WP_011251285.1 NZ_CP102870:69387-69698 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT254342 WP_011251286.1 NZ_CP102870:69695-70114 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|