Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 722296..723071 Replicon chromosome
Accession NZ_CP102869
Organism Klebsiella pneumoniae strain KA2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NWT85_RS03580 Protein ID WP_004150910.1
Coordinates 722586..723071 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NWT85_RS03575 Protein ID WP_004150912.1
Coordinates 722296..722589 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT85_RS03555 (NWT85_03555) 717504..718106 - 603 WP_002916735.1 short chain dehydrogenase -
NWT85_RS03560 (NWT85_03560) 718204..719115 + 912 WP_004188550.1 LysR family transcriptional regulator -
NWT85_RS03565 (NWT85_03565) 719116..720264 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NWT85_RS03570 (NWT85_03570) 720275..721651 - 1377 WP_004217775.1 cystathionine beta-synthase -
NWT85_RS03575 (NWT85_03575) 722296..722589 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NWT85_RS03580 (NWT85_03580) 722586..723071 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NWT85_RS03585 (NWT85_03585) 723775..724368 + 594 WP_004188553.1 hypothetical protein -
NWT85_RS03590 (NWT85_03590) 724465..724681 + 217 Protein_704 transposase -
NWT85_RS03595 (NWT85_03595) 725287..726159 + 873 WP_004188557.1 ParA family protein -
NWT85_RS03600 (NWT85_03600) 726159..726542 + 384 WP_004150906.1 hypothetical protein -
NWT85_RS03605 (NWT85_03605) 726535..727902 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 724465..724617 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T254330 WP_004150910.1 NZ_CP102869:722586-723071 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT254330 WP_004150912.1 NZ_CP102869:722296-722589 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References