Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4499940..4500542 Replicon chromosome
Accession NZ_CP102853
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NWH85_RS21830 Protein ID WP_000897305.1
Coordinates 4500231..4500542 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NWH85_RS21825 Protein ID WP_000356397.1
Coordinates 4499940..4500230 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS21800 (4495865) 4495865..4496767 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NWH85_RS21805 (4496764) 4496764..4497399 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NWH85_RS21810 (4497396) 4497396..4498325 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NWH85_RS21815 (4498655) 4498655..4498897 - 243 WP_001087409.1 protein YiiF -
NWH85_RS21820 (4499117) 4499117..4499335 - 219 WP_001315930.1 CopG family transcriptional regulator -
NWH85_RS21825 (4499940) 4499940..4500230 - 291 WP_000356397.1 NadS family protein Antitoxin
NWH85_RS21830 (4500231) 4500231..4500542 - 312 WP_000897305.1 hypothetical protein Toxin
NWH85_RS21835 (4500771) 4500771..4501679 + 909 WP_001162704.1 alpha/beta hydrolase -
NWH85_RS21840 (4501743) 4501743..4502684 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NWH85_RS21845 (4502729) 4502729..4503166 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NWH85_RS21850 (4503163) 4503163..4504035 - 873 WP_000920762.1 virulence factor BrkB family protein -
NWH85_RS21855 (4504029) 4504029..4504628 - 600 WP_001295269.1 glucose-1-phosphatase -
NWH85_RS21860 (4504727) 4504727..4505512 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T254306 WP_000897305.1 NZ_CP102853:c4500542-4500231 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT254306 WP_000356397.1 NZ_CP102853:c4500230-4499940 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References