Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 398750..399257 Replicon chromosome
Accession NZ_CP102850
Organism Gordonia mangrovi strain HNM0687

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NWF22_RS01915 Protein ID WP_258321409.1
Coordinates 399039..399257 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NWF22_RS01910 Protein ID WP_129907290.1
Coordinates 398750..399052 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWF22_RS01885 (NWF22_01885) 393778..394530 + 753 WP_160900878.1 hypothetical protein -
NWF22_RS01890 (NWF22_01890) 395266..396453 - 1188 WP_160900877.1 winged helix DNA-binding domain-containing protein -
NWF22_RS01895 (NWF22_01895) 396664..397599 + 936 WP_160900876.1 ATP-binding cassette domain-containing protein -
NWF22_RS01900 (NWF22_01900) 397596..398399 + 804 WP_160900875.1 ABC transporter permease -
NWF22_RS01905 (NWF22_01905) 398469..398753 - 285 WP_160900874.1 antibiotic biosynthesis monooxygenase -
NWF22_RS01910 (NWF22_01910) 398750..399052 - 303 WP_129907290.1 HigA family addiction module antitoxin Antitoxin
NWF22_RS01915 (NWF22_01915) 399039..399257 - 219 WP_258321409.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWF22_RS01920 (NWF22_01920) 399354..400433 - 1080 WP_160900872.1 redox-regulated ATPase YchF -
NWF22_RS01925 (NWF22_01925) 400597..401826 - 1230 WP_258321410.1 AI-2E family transporter -
NWF22_RS01930 (NWF22_01930) 401938..402267 - 330 WP_160900871.1 hypothetical protein -
NWF22_RS01935 (NWF22_01935) 402387..404060 + 1674 WP_258321298.1 Ada metal-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-72)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-85)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8230.28 Da        Isoelectric Point: 6.2121

>T254280 WP_258321409.1 NZ_CP102850:c399257-399039 [Gordonia mangrovi]
IDPRIHRVALRKLRQVGSAESLDDLTVPPGNRLEALKGDRAGQHSIRINDQWRICFVWADTGPEEVEIVDYH

Download         Length: 219 bp

>T254280 NZ_CP102850:c399257-399039 [Gordonia mangrovi]
ATCGATCCGCGGATTCACCGGGTCGCGCTGCGCAAACTTCGTCAGGTGGGATCGGCAGAGTCGCTCGACGACCTCACGGT
CCCACCCGGGAATCGGCTCGAAGCACTGAAAGGTGATCGGGCGGGACAACACAGCATCAGAATCAATGACCAGTGGCGAA
TCTGCTTCGTCTGGGCGGACACTGGGCCGGAGGAGGTCGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10960.52 Da        Isoelectric Point: 5.5740

>AT254280 WP_129907290.1 NZ_CP102850:c399052-398750 [Gordonia mangrovi]
MTTTDKIAPIHPGEVLMEDFIEGFGITQNKLAVSVGVPPRRINEIVHGKRAISADTALRLGKYFGTSAQFWLNLQSHYDL
DLAEDRAAEQIAAIIPLQSA

Download         Length: 303 bp

>AT254280 NZ_CP102850:c399052-398750 [Gordonia mangrovi]
TTGACTACCACTGACAAGATCGCGCCGATCCATCCCGGGGAAGTCCTCATGGAGGACTTCATCGAAGGTTTCGGCATCAC
GCAGAACAAGTTGGCGGTGTCAGTGGGTGTGCCTCCGCGGCGCATCAATGAGATCGTGCACGGCAAGCGCGCGATCAGCG
CTGACACGGCCTTGCGACTTGGGAAGTACTTTGGCACATCGGCTCAATTCTGGCTCAATCTGCAGTCGCATTACGACCTG
GACCTCGCCGAGGACCGTGCAGCAGAGCAGATTGCCGCGATCATTCCGCTTCAGTCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References