Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 15767..16494 | Replicon | plasmid pKP0079-1 |
| Accession | NZ_CP102837 | ||
| Organism | Klebsiella pneumoniae strain KP0079 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | NV396_RS26650 | Protein ID | WP_011251285.1 |
| Coordinates | 15767..16078 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NV396_RS26655 | Protein ID | WP_011251286.1 |
| Coordinates | 16075..16494 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NV396_RS26625 (NV396_26625) | 11286..11780 | - | 495 | WP_004212794.1 | thermonuclease family protein | - |
| NV396_RS26630 (NV396_26630) | 11958..12224 | + | 267 | WP_223175074.1 | DUF1173 family protein | - |
| NV396_RS26635 (NV396_26635) | 12257..12907 | + | 651 | WP_068893702.1 | DUF1173 family protein | - |
| NV396_RS26645 (NV396_26645) | 15125..15562 | + | 438 | Protein_12 | DDE-type integrase/transposase/recombinase | - |
| NV396_RS26650 (NV396_26650) | 15767..16078 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NV396_RS26655 (NV396_26655) | 16075..16494 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NV396_RS26660 (NV396_26660) | 16641..17609 | + | 969 | WP_074428168.1 | IS5 family transposase | - |
| NV396_RS26665 (NV396_26665) | 17681..18046 | - | 366 | WP_048333448.1 | hypothetical protein | - |
| NV396_RS26670 (NV396_26670) | 18060..18848 | - | 789 | WP_040217257.1 | hypothetical protein | - |
| NV396_RS26675 (NV396_26675) | 18869..19489 | - | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| NV396_RS26680 (NV396_26680) | 19908..20543 | + | 636 | WP_223171879.1 | hypothetical protein | - |
| NV396_RS26685 (NV396_26685) | 20856..21326 | + | 471 | WP_048333570.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..194877 | 194877 | |
| - | inside | IScluster/Tn | - | - | 269..24334 | 24065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T254251 WP_011251285.1 NZ_CP102837:15767-16078 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT254251 WP_011251286.1 NZ_CP102837:16075-16494 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|