Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 9617..10268 Replicon plasmid pAB3927
Accession NZ_CP102832
Organism Acinetobacter baumannii strain AB3927

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag NV385_RS19370 Protein ID WP_000269904.1
Coordinates 9912..10268 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NV385_RS19365 Protein ID WP_001129974.1
Coordinates 9617..9919 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV385_RS19335 (NV385_19335) 4629..4928 + 300 WP_000358348.1 hypothetical protein -
NV385_RS19340 (NV385_19340) 5196..5483 + 288 WP_000438827.1 BrnT family toxin -
NV385_RS19345 (NV385_19345) 5470..5784 + 315 WP_001983304.1 BrnA antitoxin family protein -
NV385_RS19350 (NV385_19350) 5912..8323 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
NV385_RS19355 (NV385_19355) 8628..9089 + 462 WP_000761346.1 DIP1984 family protein -
NV385_RS19360 (NV385_19360) 9415..9624 - 210 WP_000069474.1 hypothetical protein -
NV385_RS19365 (NV385_19365) 9617..9919 - 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
NV385_RS19370 (NV385_19370) 9912..10268 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV385_RS19375 (NV385_19375) 10834..11133 - 300 WP_000358348.1 hypothetical protein -
NV385_RS19380 (NV385_19380) 11250..12011 - 762 WP_000425105.1 hypothetical protein -
NV385_RS19385 (NV385_19385) 12316..13485 + 1170 WP_002134206.1 MobA/MobL family protein -
NV385_RS19390 (NV385_19390) 14082..15017 + 936 WP_001292329.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22388 22388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T254219 WP_000269904.1 NZ_CP102832:c10268-9912 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT254219 WP_001129974.1 NZ_CP102832:c9919-9617 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References