254195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 33773..34431 Replicon plasmid unnamed4
Accession NZ_CP102820
Organism Acinetobacter baumannii strain AB186-VUB

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2Z19_RS18865 Protein ID WP_000312250.1
Coordinates 34072..34431 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2Z19_RS18860 Protein ID WP_099715069.1
Coordinates 33773..34072 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z19_RS18830 (L2Z19_18855) 29300..29434 + 135 WP_261944414.1 hypothetical protein -
L2Z19_RS18835 (L2Z19_18860) 29511..29852 + 342 WP_079757915.1 hypothetical protein -
L2Z19_RS18840 (L2Z19_18865) 30222..31310 - 1089 Protein_45 IS4-like element ISAba1 family transposase -
L2Z19_RS18845 (L2Z19_18870) 31408..32228 + 821 Protein_46 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase -
L2Z19_RS18850 (L2Z19_18875) 32333..32992 - 660 Protein_47 ATP-binding protein -
L2Z19_RS18855 (L2Z19_18880) 33033..33236 + 204 WP_000389756.1 hypothetical protein -
L2Z19_RS18860 (L2Z19_18885) 33773..34072 - 300 WP_099715069.1 XRE family transcriptional regulator Antitoxin
L2Z19_RS18865 (L2Z19_18890) 34072..34431 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Z19_RS18870 (L2Z19_18895) 34632..35198 + 567 WP_000710385.1 hypothetical protein -
L2Z19_RS18875 (L2Z19_18900) 35247..35429 + 183 WP_000373385.1 hypothetical protein -
L2Z19_RS18880 (L2Z19_18905) 35496..36194 + 699 WP_000873188.1 hypothetical protein -
L2Z19_RS18885 (L2Z19_18910) 36457..36714 + 258 WP_002013718.1 hypothetical protein -
L2Z19_RS18890 (L2Z19_18915) 36861..37538 + 678 WP_261944415.1 hypothetical protein -
L2Z19_RS18895 (L2Z19_18920) 38589..38903 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 / aph(3')-VIa - 1..76819 76819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T254195 WP_000312250.1 NZ_CP102820:c34431-34072 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11027.00 Da        Isoelectric Point: 10.5709

>AT254195 WP_099715069.1 NZ_CP102820:c34072-33773 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDIKLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References