Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2028..2613 Replicon plasmid pAOR07BL-3
Accession NZ_CP102765
Organism Acinetobacter baumannii strain AOR07-BL

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag NU955_RS19320 Protein ID WP_000897309.1
Coordinates 2293..2613 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NU955_RS19315 Protein ID WP_000369780.1
Coordinates 2028..2300 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU955_RS19305 71..898 + 828 WP_032495421.1 AraC family transcriptional regulator -
NU955_RS19310 948..1553 + 606 WP_000447788.1 LysE family translocator -
NU955_RS19315 2028..2300 - 273 WP_000369780.1 NadS family protein Antitoxin
NU955_RS19320 2293..2613 - 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NU955_RS19325 2800..2997 - 198 WP_000476222.1 hypothetical protein -
NU955_RS19330 3064..3291 - 228 WP_000921865.1 hypothetical protein -
NU955_RS19335 3390..3605 - 216 WP_000071892.1 cold-shock protein -
NU955_RS19340 3931..4650 - 720 WP_001218546.1 hypothetical protein -
NU955_RS19345 4668..4934 - 267 WP_188200041.1 mobilization protein -
NU955_RS19350 5145..6581 + 1437 WP_059264791.1 MobQ family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..31683 31683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T254162 WP_000897309.1 NZ_CP102765:c2613-2293 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10122.63 Da        Isoelectric Point: 8.6582

>AT254162 WP_000369780.1 NZ_CP102765:c2300-2028 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure

References