Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 226062..226664 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag NWA04_RS01150 Protein ID WP_023138876.1
Coordinates 226062..226373 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NWA04_RS01155 Protein ID WP_000362052.1
Coordinates 226374..226664 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS01115 (221175) 221175..221774 + 600 WP_000965695.1 glucose-1-phosphatase -
NWA04_RS01120 (221768) 221768..222640 + 873 WP_000921423.1 virulence factor BrkB family protein -
NWA04_RS01125 (222637) 222637..223074 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NWA04_RS01130 (223119) 223119..224060 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NWA04_RS01135 (224075) 224075..224521 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NWA04_RS01140 (224518) 224518..224829 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NWA04_RS01145 (224915) 224915..225844 - 930 WP_001127698.1 alpha/beta hydrolase -
NWA04_RS01150 (226062) 226062..226373 + 312 WP_023138876.1 hypothetical protein Toxin
NWA04_RS01155 (226374) 226374..226664 + 291 WP_000362052.1 DNA-binding transcriptional regulator Antitoxin
NWA04_RS01160 (226711) 226711..227640 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NWA04_RS01165 (227637) 227637..228272 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NWA04_RS01170 (228269) 228269..229171 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T254141 WP_023138876.1 NZ_CP102756:226062-226373 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10970.65 Da        Isoelectric Point: 11.0303

>AT254141 WP_000362052.1 NZ_CP102756:226374-226664 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References