Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 31137..31794 Replicon chromosome
Accession NZ_CP102749
Organism Pectobacterium parvum strain YT22221

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NV347_RS00140 Protein ID WP_039485180.1
Coordinates 31423..31794 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A433N287
Locus tag NV347_RS00135 Protein ID WP_010281167.1
Coordinates 31137..31436 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV347_RS00115 (NV347_00115) 26390..27379 + 990 WP_039485171.1 nucleoside hydrolase -
NV347_RS00120 (NV347_00120) 27379..28356 + 978 WP_010296900.1 ABC transporter permease -
NV347_RS00125 (NV347_00125) 28353..29261 + 909 WP_039485174.1 ABC transporter permease -
NV347_RS00130 (NV347_00130) 29301..31100 + 1800 WP_258210302.1 ABC transporter ATP-binding protein -
NV347_RS00135 (NV347_00135) 31137..31436 - 300 WP_010281167.1 XRE family transcriptional regulator Antitoxin
NV347_RS00140 (NV347_00140) 31423..31794 - 372 WP_039485180.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV347_RS00145 (NV347_00145) 32132..32830 + 699 WP_039485183.1 D-galactonate utilization transcriptional regulator DgoR -
NV347_RS00150 (NV347_00150) 32827..33723 + 897 WP_039485185.1 2-dehydro-3-deoxygalactonokinase -
NV347_RS00155 (NV347_00155) 33707..34324 + 618 WP_111778603.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
NV347_RS00160 (NV347_00160) 34321..35469 + 1149 WP_005976723.1 galactonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14144.08 Da        Isoelectric Point: 4.8510

>T254124 WP_039485180.1 NZ_CP102749:c31794-31423 [Pectobacterium parvum]
MAWEIVTRALFDTWFDEQTEAVQEEILAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IILCAGDKKGEDEKLFYERMIKIADAEFTSHLISPEVKEDGNA

Download         Length: 372 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.08 Da        Isoelectric Point: 10.6442

>AT254124 WP_010281167.1 NZ_CP102749:c31436-31137 [Pectobacterium parvum]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A433N287

References