Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1826389..1826908 Replicon chromosome
Accession NZ_CP102746
Organism Streptococcus suis strain Transconjugant cAKJ47-2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag NWE23_RS08935 Protein ID WP_012775363.1
Coordinates 1826389..1826646 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NWE23_RS08940 Protein ID WP_002939010.1
Coordinates 1826648..1826908 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE23_RS08920 (NWE23_08930) 1822858..1824588 - 1731 WP_012775361.1 membrane protein -
NWE23_RS08925 (NWE23_08935) 1824953..1825825 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NWE23_RS08930 (NWE23_08940) 1825845..1826375 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NWE23_RS08935 (NWE23_08945) 1826389..1826646 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
NWE23_RS08940 (NWE23_08950) 1826648..1826908 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWE23_RS08945 (NWE23_08955) 1826984..1827313 - 330 Protein_1722 NUDIX domain-containing protein -
NWE23_RS08950 (NWE23_08960) 1827435..1828877 - 1443 WP_228475522.1 recombinase family protein -
NWE23_RS08955 (NWE23_08965) 1828864..1830480 - 1617 WP_044980247.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T254111 WP_012775363.1 NZ_CP102746:c1826646-1826389 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT254111 WP_002939010.1 NZ_CP102746:c1826908-1826648 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References