Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 225996..226598 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag NWA03_RS01155 Protein ID WP_023138876.1
Coordinates 225996..226307 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NWA03_RS01160 Protein ID WP_000362052.1
Coordinates 226308..226598 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS01120 (221109) 221109..221708 + 600 WP_000965695.1 glucose-1-phosphatase -
NWA03_RS01125 (221702) 221702..222574 + 873 WP_000921423.1 virulence factor BrkB family protein -
NWA03_RS01130 (222571) 222571..223008 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NWA03_RS01135 (223053) 223053..223994 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NWA03_RS01140 (224009) 224009..224455 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NWA03_RS01145 (224452) 224452..224763 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NWA03_RS01150 (224849) 224849..225778 - 930 WP_001127698.1 alpha/beta hydrolase -
NWA03_RS01155 (225996) 225996..226307 + 312 WP_023138876.1 hypothetical protein Toxin
NWA03_RS01160 (226308) 226308..226598 + 291 WP_000362052.1 DNA-binding transcriptional regulator Antitoxin
NWA03_RS01165 (226645) 226645..227574 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NWA03_RS01170 (227571) 227571..228206 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NWA03_RS01175 (228203) 228203..229105 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T254086 WP_023138876.1 NZ_CP102739:225996-226307 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10970.65 Da        Isoelectric Point: 11.0303

>AT254086 WP_000362052.1 NZ_CP102739:226308-226598 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References